Growth Hormone Treatment in Adults with Growth Hormone Deficiency: Effect on Muscle Fibre Size and Proportions

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Abstract
Whitehead, H.M., Gilliland, J.S., Allen, I.V. and Hadden D.R. (Sir George E. Clark Metabolic Unit and the Department of Neuropathology, Royal Victoria Hospital, Belfast, Northern Ireland, UK). Growth hormone treatment in adults with growth hormone deficiency: effect on muscle fibre size and proportions. Acta Paediatr Scand [Suppl] 356: 65, 1989.The effect of a 6‐month period of substitution therapy with recombinant human growth hormone (rhGH) on muscle fibre size and muscle fibre type proportions has been investigated in a group of 13 adults with growth hormone deficiency. All had a peak growth hormone (GH) response to insulin‐induced hypoglycaemia of less than 7 mU/I. There was no statistically significant change in the lesser fibre diameter or fibre proportions of either type 1 or type 2 muscle fibres in the rhGH group, as compared with placebo.