The Immune System
Top Cited Papers
- 6 July 2000
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 343 (1) , 37-49
- https://doi.org/10.1056/nejm200007063430107
Abstract
The immune system is an organization of cells and molecules with specialized roles in defending against infection. There are two fundamentally different types of responses to invading microbes. Innate (natural) responses occur to the same extent however many times the infectious agent is encountered, whereas acquired (adaptive) responses improve on repeated exposure to a given infection. The innate responses use phagocytic cells (neutrophils, monocytes, and macrophages), cells that release inflammatory mediators (basophils, mast cells, and eosinophils), and natural killer cells. The molecular components of innate responses include complement, acute-phase proteins, and cytokines such as the interferons. Acquired responses involve the proliferation of . . .Keywords
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