Penicillamine-lnduced Elastosis perforans serpiginosa Treated Successfully with Isotretinoin

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Abstract
Elastosis perforans serpiginosa (EPS) and the elastotic changes of pseudoxanthoma elasticum (PXE) are rare but well recognized side effects of long-term penicillamine therapy. A 42-year old female patient who developed both of these cutaneous side effects following treatment with high-dose peniciUamine for Wilson’s disease is described; near-complete resolution of the EPS, but not the PXE was achieved by treatment with isotretinoin (0.5 mg/kg/day) for 6 weeks, despite continuation of the penicillamine.

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