Quantitative Occurrence of Bacteria in Hyperplastic Prostatic Tissue and its Correlation to Bacteriuria

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Abstract
The method developed for quantitative culture from tissue homogenate and urine is described and the standard error given. A bacterial count was performed from the enucleated adenoma in 92 cases of benign prostatic hyperplasia. In 82 of the cases an additional bacterial count was made from urine taken at the operation by catheter or puncture. Both the adenomatous tissue and the urine were practically sterile ( < 1 × 102 bacteria per g of tissue and < 1 × 104 bacteria per ml of urine) in 41 out of 82 cases. The next largest group consisted of 24 cases in which the bacterial content of the adenomatous tissue was > 1 x 102 and the bacteriuria > 1 × 104 bacteria per ml. There were, in addition, two small groups with the combination infected adenomatous tissue and sterile urine, and sterile adenoma and infected urine. In the cases with infected adenomatous tissue and significant urinary infection a statistically significant correlation was found between the bacterial contents of the two media. The bacterial content of the adenoma was lower than that of the urine. The result of dipping sterile prostatic adenoma in infected urine showed that the bacterial content of the adenomatous tissue in the cases with infected urine was probably derived from contamination by infected urine at operation. The possibility of an antibacterially active substance in prostatic tissue is discussed.