Dominant Nonresponsiveness toHelicobacter pyloriInfection Is Associated with Production of Interleukin 10 but Not Gamma Interferon
Open Access
- 1 August 2000
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (8) , 4802-4804
- https://doi.org/10.1128/iai.68.8.4802-4804.2000
Abstract
Helicobacter pylori-induced gastritis is an essential precursor lesion for the development of peptic ulcers or gastric adenocarcinoma. We demonstrate that nonresponsiveness toH. pyloriSS1 infection is dominantly inherited in mice. F1hybrid crosses between a nonresponder mouse and three responder strains all possessed the nonresponder phenotype. Secretion of interleukin-10 but not gamma interferon was associated with nonresponsiveness to infection.Keywords
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