Vascular Leakage Induced by Horseradish Peroxidase in the Rat.

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Abstract
Intradermal, intraperitoneal and intravenous injections of horseradish peroxidase solutions induce increased vascular permeability in rats. The vascular leakage is confined to venules, is of short duration, can be inhibited by a combination of histamine and serotonin [5-hydroxytryptamine] antagonists and is associated with mast cell degranulation. This phenomenon occurs also in the guinea pig but is minimal or non-existent in the mouse and in the Wistar/ Furth rat.