Abstract
A SERIES of articles on the use of antihistaminic drugs in the prevention and early treatment of common colds has appeared since the first paper by Brewster1 in 1947. Several early and very optimistic medical reports were quoted widely in lay periodicals. These did much to stimulate heavy over-the-counter sales of antihistamine drugs in the winter of 1949–50. In more recent reports2 , 3 the trend of opinion has been against the efficacy of antihistamines in the treatment of the common cold. In contrast to some of the earlier reports, the studies of Cowan and Diehl2 and Feller et al.3 were well . . .