Tolerance Induction via Antigen Inhalation: Isotype Specificity, Stability, and Involvement of Suppressor T Cells
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 67 (2) , 155-160
- https://doi.org/10.1159/000233007
Abstract
Mice were exposed to aerosolized ovalbumin (OA) once weekly for 5 min on 6 occasions, prior to systemic challenge with soluble or alum-adsorbed (AH-OA) antigen. Mice challenged with AH-OA manifested profound IgE isotype-specific tolerance; those challenged with soluble OA initially manifested anamnestic IgE/IgG responses, but secondary intraperitoneal immunization 13 days later with soluble OA revealed IgE isotype-specific tolerance. The tolerized mice contained splenic suppressor T cells which inhibited IgE but not IgG responses in an adoptive transfer assay. Tolerance was still demonstrable in mice 6 months after the cessation of aerosol exposures. Exposure of low IgE responder rat strains to aerosolized OA tolerized for both IgE and IgG responses.This publication has 1 reference indexed in Scilit:
- Adoptive Transfer of ‘Persistent’ IgE Responses in Mice in the Absence of Secondary Antigenic StimulationInternational Archives of Allergy and Immunology, 1981