Ionic Flux Across the Gastric Mucosa: Effects of Atropine on the Permeability of Fundus and Antrum

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Abstract
The effects of atropine were evaluated on ionic movement across fundic and antral mucosa. 0.16 N HCl solutions were instilled into vagally denervated fundic and antral pouches. Atropine (0.05 mg/kg) increased the mean net loss of H+ ions in both pouches, but to a slightly greater extent in the fundus (86%) than in the antrum (66%). Although the mechanism of action is speculative, it is suggested that the diminished acid output in gastric secretion following atropine may be due to secretory inhibition, and to a lesser extent, a transmucosal loss of hydrogen ions.

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