Uncoupled synthesis of H1°‐like histone H1s during late erythropoiesis in Xenopus laevis

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Abstract
The synthesis of Xenopus histones was investigated during erythropoiesis. Although cessation of DNA replication in the mid-stages of erythroid maturation is accompanied by arrested synthesis of histone H1 and core histones, synthesis of H1s (an H1o-like histone) continued into late stages of erythropoiesis, as has been reported for avian erythrocyte histone H5. This was accompanied by a 3-fold increase in the relative amount of Xenopus H1s, similar to the accumulation reported for H5 during avian erythropoiesis and for H1o in some differentiated mammalian cells. The structural and metabolic homologies of avian H5, mammalian H1o, and Xenopus H1s imply that these lysine-rich histones have closely related functions distinct from those of H1, and thus represent a subclass of lysine-rich histones.