Reversibility of Chronic Neurologic Deficits. Some Effects of Electrical Stimulation of the Thalamus and Internal Capsule in Man

Abstract
Stimulation of the thalamus and internal capsule with Medtronic® deep brain stimulation electrodes produced improvement in pain, hemiparesis, dystonia, torticollis, tremor, speech impairment and epilepsy. Stimulation at voltages above or below clinically effective levels (e.g., 6 V, 0.3 ms, 74 Hz) resulted in a loss of clinical efficacy. Somatosensory evoked responses (short and long latency) and depth electrode recordings were helpful in localisation and ‘biocalibration’ of electrical stimulation.

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