METABOLIC AND HORMONAL FACTORS INFLUENCING EXTRA-RENAL BUFFERING OF AN ACUTE ACID LOAD

  • 1 January 1982
    • journal article
    • research article
    • Vol. 8  (1) , 36-43
Abstract
Metabolic and hormmonal factors influencing extrarenal buffering of an acute acid load were studied. Phosphate deprivation of 2 wk duration was associated with enhanced extrarenal acid buffering. The enhanced buffering capacity of phosphate deprivation was not dependent on the presence of parathyroid glands. Parathyroid hormone administration to phosphate-deprived rats promoted a further enhancement of the buffering capacity of an acid load. Blood pH and HCO3 during acid loading were not significantly different between control anhd diphosphonate-treated rats and between phosphate-deprived rats and phosphate-deprived rats treated with diphosphonate. The mortality rate, however, was significantly higher in diphosphonate-treated rats than in rats not receiving the drug suggesting that diphosphonate blunts the buffering of an acid load in control and phosphate-deprived rats. Chronic vitamin D administration and acute administration of arginine vasopressin in pharmacologic doses were associated with significant enhancement of buffering capacity as compared to control rats. Thyrocalcitonin administration to intact but not thyroparathyroidectomized rats was associated with diminished capacity to buffer an acid load. Evidently, the buffering of an acute acid loads is influenced by a number of dietary and hormonal factors probably acting at the level of the bone.

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