Hepatic fibrosis produced in rats by repeated intraperitoneal injections of swine serum.

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Abstract
Pathological observations were made on male Sprague-Dawley rats which had received i.p. injections of sterile swine serum twice a week for 12 wk. Changes were found mainly in the liver, kidneys and spleen. In the liver, pseudolobules were formed in all animals after 8 or more weeks. Proliferation of collagen fibers was detected 1st around the central veins and in the portal tracts after 3 wk, and then in the space of Disse. After 8 or more weeks, numerous fat-storing cells (Ito''s cells) were found in the collagen septa subdividing the lobules. In the initial stage of fibrosis, infiltration of eosinophils and mast cells was observed around the central veins and in the portal tracts. There were no noticeable changes, however, in hepatocytes or sinusoidal lining cells throughout the experimental period. In the kidneys, fine electron-dense deposits were found in the mesangial area of glomeruli after 4 or more weeks. In the corresponding sites, specific fluorescence of rat IgG was detected by the immunofluorescence technique. In the spleen, swelling and increased lymphatic follicles with active germinal centers were noticed after 2 or more weeks.

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