Function of Macrophage Prostaglandins in the Process of Phagocytosis

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Abstract
Prostaglandins (PGs) act as mediators in inflammation and cell-mediated immune responses (1,5,9). Since macrophages participate in the inflammatory reaction, studies were focused on the effects of PGs on macrophage functions. It has been demonstrated that addition of PGs at low doses enhances phagocytosis (8), whereas at pharmacological concentrations phagocytosis is inhibited (2,7,8,10). Furthermore, macrophages were shown to synthesize PGs (3,4), and this process is enhanced by phagocytized particles (6). We therefore attempted to find out whether synthesis of PGs by the macrophage may play a role in phagocytosis.