Laboratory and Clinical Evaluation of White Blood Cell Differential Counts: Comparison of the Coulter VCS, Technicon H-1, and 800 Cell Manual Method
- 1 March 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 95 (3) , 381-388
- https://doi.org/10.1093/ajcp/95.3.381
Abstract
Eight hundred-cell manual white blood cell differential count evaluations of Coulter VCSTM and Technicon H-lTM included estimates of accuracy, imprecision, random and systematic errors, clinical relevance, and detection of immature neutrophils. Accuracy was acceptable, except for H-l testing of monocytes. Instrument imprecision was similar, except for tighter monocyte values as measured by the VCS. Deming regression determined random errors were greater for H-l monocytes and proportional errors were similar. Constant errors for the VCS were less than the H-l for neutrophils and monocytes and greater than the H-1 for eosinophils and lymphocytes. H-l morphologic false-negative rates were twice those for VCS. True-positive and falsenegative rates in cases with immature neutrophils were 70.6% and 20.3% for the VCS and 35% and 55.9% for the H-l. The reference false-positive rate was 4.4%. Clinically appropriate VCS flags were generated in distributionally abnormal cases. Predictive values were higher for the VCS.Keywords
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