Asymmetric Synthesis of Homoallylamines by Nucleophilic Addition of Chirally Modified Allylboron Reagent to N-Borylimines

31 December 1999

journal article
letter
Published by Georg Thieme Verlag KG in Synlett

Vol. 1999 (12) , 1987-1989
https://doi.org/10.1055/s-1999-2996

Abstract

One pot synthesis of enantioenriched homoallylamines from nitriles is described. Chirally modified allylboron reagents reacted with N-borylimines derived from partial reduction of nitriles with LiEt₃BH to afford enantioenriched homoallylamines in up to 90% ee.

Keywords

N-BORYLIMINE
HOMOALLYLAMINE
NITRILE
LIET3BH
ALLYLBORATION

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