I-J expression is not associated with murine chromosome 4

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Abstract
I‐J originally mapped within the murine major histocompatibility complex (H‐2) between the EB and Ea, loci using intra‐H‐2 recombinants. Cloning of this segment of H‐2 shows no DNA that can be ascribed to I‐J. Various hypotheses have attempted to explain this dilemma. One hypothesis attributes a chromosome 4 locus with I‐Jk expression. This hypothesis requires the AKR/J and A/WySn mouse strains to be I‐Jk negative. In the present report we show that AKR/J spleen cells express I‐Jk surface molecules and that both the AKR/J and A/WySn mouse strains produce functional I‐Jk‐bearing suppressor factors to poly(Glu50Tyr50). Our data imply that mapping of I‐J‐determining genes to chromosome 4 may be premature.

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