Studies on Sustained Release Iii: Matrix Granules of Sulfamethizole

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Abstract
Polymethylmethacrylate and cellulose acetate phtalate has been employed for the preparation of matrix sustained release sulfamethizole granules. The effect of various adjuvants on the release profile is also investigated. It is seen that, this type of sustained release is suitable for high values of release rate in contrast to inert matrix type tablets. The kinetics of release is not zero order, but RRSBW distribution seems to give better fits. Cellulose acetate phtalate warrants further work in such formulations; possibly with the concurrent employment of other polymers.