Familial occurrence of a developmental defect of the medial nasal processes

Publisher Website
Google Scholar
Abstract
We report on a family in which the propositus and two distant relatives have a wide nose, broad philtrum, and short columella, a fusion defect of the medial nasal processes. This anomaly resembles potato nose [Benjamins and Stibbe, Acta Otolaryngol 11:274–284, 1927] and bifid nose [Anyane‐Yeboa et al, Am J Med Genet 17:561–563, 1984], which are also fusion anomalies of the medial nasal processes. Potato nose is an autosomal dominant trait, whereas bifid nose is likely heterogeneous. In this family autosomal recessive inheritance is likely, therefore suggesting that anomalies of the medial nasal processes are causally heterogeneous and represent a developmental field defect.

This publication has 5 references indexed in Scilit: