Streptozotocin-Diabetes in the Chinese Hamster
- 1 January 1972
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 4 (06) , 426-433
- https://doi.org/10.1055/s-0028-1094000
Abstract
Intraperitoneal administration of 200 mg/kg body weight of streptozotocin to non-diabetic adult Chinese hamsters, evoked a triphasic blood glucose response. There was a hyperglycemic peak after 3 hours and a hypoglycemic phase with a minimum at 6 hours, after which time there was a rather rapid return to hyperglycemia. Light and electron microscopic examinations during the first 24 hours after the injection of streptozotocin showed pyknosis, vacuolization, marked degeneration and necrosis of the β-cells. Degenerative and necrotic changes were also seen in a few α2-cells. The results denote that in the Chinese hamster streptozotocin has an early and direct cytotoxic action on the β-cells and probably also on a few α2-cells. 1 Supported by grants from the Swedish Medical Research Council (Project No. B72-12X-718-07A), the Swedish Diabetes Foundation and the Medical Faculty of Umeå.Keywords
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