EFFECTS OF CIGUATOXIN AND MAITOTOXIN ON THE ISOLATED GUINEA-PIG ATRIA

  • 1 January 1979
    • journal article
    • research article
    • Vol. 25  (1) , 177-180
Abstract
The effects of ciguatoxin (CT) and maitotoxin (MT) were studied on the isolated atria of the guinea pig. Application of CT evoked a prolonged positive inotropic effects on the electrically-driven atria and inotropic and chronotropic effects on the spontaneously-beating right atria. The response to MT, in contrast, was biphasic. At low concentration (10-8 gm/ml) MT enhanced the atrial contractility; at higher concentrations (5 .times. 10-8 gm/ml) it depressed the atria, frequently to a standstill. CT and MT have a direct action on the contractile mechanism of the heart and their effects are readily distinguishable.

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