ANTI-HBV SPECIFIC β-L-2′-DEOXYNUCLEOSIDES
- 31 March 2001
- journal article
- review article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 20 (4-7) , 597-607
- https://doi.org/10.1081/ncn-100002336
Abstract
A unique series of simple unnatural L-nucleosides that specifically inhibit hepatitis B virus (HBV) replication has been discovered. These molecules have in common a hydroxyl group in the 3'-position (3'-OH) of the beta-L-2'-deoxyribose sugar that confers antiviral activity specifically against hepadnaviruses. Replacement of the 3'-OH broadens activity to other viruses. Substitution in the base decreases antiviral potency and selectivity. Human DNA polymerases and mitochondrial function are not effected. Plasma viremia is reduced up to 8 logs in a woodchuck model of chronic HBV infection. These investigational drugs, used alone or in combination, are expected to offer new therapeutic options for patients with chronic HBV infection.Keywords
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