The adjuvanticity of interleukin 1 in vivo.
Open Access
- 1 May 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 130 (5) , 2191-2194
- https://doi.org/10.4049/jimmunol.130.5.2191
Abstract
Interleukin 1 (IL 1) was shown to enhance in vivo secondary antibody responses of mice to a protein antigen. The activity was found to be dose and time dependent. The maximum enhancing effect was obtained with 2000 LAF units of IL 1 given 2 hr after the priming dose of antigen. The observation is consistent with the in vitro immunoenhancing activities of IL 1 and strongly suggests that this protein may be an important mediator of host defense responses, as well as of the stimulatory effects of some adjuvants.This publication has 1 reference indexed in Scilit:
- Components of mycobacteria and muramyl dipeptide with adjuvant activity induce lymphocyte activating factorPublished by Elsevier ,2004