Exacerbations in Chronic Obstructive Pulmonary Disease: Do They Contribute to Disease Progression?
- 1 December 2007
- journal article
- review article
- Published by American Thoracic Society in Proceedings of the American Thoracic Society
- Vol. 4 (8) , 586-590
- https://doi.org/10.1513/pats.200706-068TH
Abstract
The impact of chronic obstructive pulmonary disease (COPD) exacerbations on decline in FEV1 has been a controversial topic for decades. We will review some of the key studies in this area and discuss potential contributors to inconsistent results of these studies. Dissecting the heterogeneous COPD syndrome into meaningful subtypes and assessing the genetic and environmental influences on COPD-related phenotypes such as exacerbation frequency could clarify the impact of exacerbations on the natural history of COPD.Keywords
This publication has 14 references indexed in Scilit:
- Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary DiseaseNew England Journal of Medicine, 2007
- Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary diseaseThorax, 2005
- Impact of preventing exacerbations on deterioration of health status in COPDEuropean Respiratory Journal, 2004
- The Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index in Chronic Obstructive Pulmonary DiseaseNew England Journal of Medicine, 2004
- Withdrawal From Treatment as an Outcome in the ISOLDE Study of COPDChest, 2003
- Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary diseaseThorax, 2002
- Lower Respiratory Illnesses Promote FEV1 Decline in Current Smokers But Not Ex-Smokers with Mild Chronic Obstructive Pulmonary DiseaseAmerican Journal of Respiratory and Critical Care Medicine, 2001
- Variables associated with changes in spirometry in patients with obstructive lung diseasesThe American Journal of Medicine, 1979
- The natural history of chronic airflow obstruction.BMJ, 1977
- A long-term follow-up of respiratory symptoms and ventilatory function in a group of working menOccupational and Environmental Medicine, 1970