Adrenocortical function in idiopathic haemochromatosis

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Abstract
In idiopathic hemochromatosis, excessive Fe deposits include adrenal cortex, mainly the zona glomerulosa. The basal and post-stimulative values of plasma cortisol, aldosterone and renin activity (RA) were measured in 2 groups of patients: 9 normal-salt repleted subjects (NSR) who were subjected to i.v. ACTH and furosemide tests, 10 patients who were subjected to chronic salt depletion (CSD), to i.v. ACTH and furosemide tests. The results were compared with 2 groups of 7 healthy volunteers (NSR and CSD). In the patients, basal cortisol values were either normal or increased in cases of poorly controlled diabetes (21 .+-. 2.1 .mu.g/100 ml, P < 0.01) and cortisol increase after ACTH injection was normal (to 43.3 .+-. 4.3 .mu.g/100 ml). In the 9 NSR patients, basal aldosterone (7.75 1.5 ng/100 ml) and RA (1.55 .+-. 0.27 ng/ml per h) values were normal; aldosterone and RA rose after furosemide injection: these increases were similar in these patients (respectively to: 13.5 .+-. 2.2 ng/100 ml and 4.3 .+-. 0.6 ng/ml per h) and in the 7 NSR controls. In the 10 CSD patients, basal aldosterone and RA values were always increased (26.5 .+-. 3.2 ng/100 ml and 8.5 .+-. 2.3 ng/ml per h) as much as in the 7 CSD controls. After ACTH administration, aldosterone values (26.1 .+-. 4 in NSR patients, 54 .+-. 8 ng/100 ml in CSD patients) were the same as in the 2 control groups. Apparently, there is no adrenocortical deficiency in idiopathic hemochromatosis, in spite of excessive Fe deposits in the adrenal cortex.

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