Changes in clinical symptomatology and psychometric assessments in depressed patients during mianserin and combined amitriptyline/ chlordiazepoxide therapy: a double-blind comparison

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Abstract
SummaryA double-blind controlled trial was carried out in 80 depressed out-patients to compare the efficacy and tolerance of mianserin with that of a fixed combination preparation of amitriptyline and chlordiazepoxide. After a wash-out period of at least 1 week, the patients were allocated at random to treatment with one or other of the trial drugs for 4 weeks. During the first week, patients received 30 mg mianserin per day or 37.5 mg amitriptyline plus 15 mg chlordiazepoxide per day. Thereafter, they received 50 mg mianserin per day or 62.5 mg amitriptyline plus 25 mg chlordiazepoxide per day. Assessments, using the Hamilton Rating Scale for Depression, the Zung Self-Rating Depression Scale, the Clinical Global Impressions Scale and a questionnaire for somatic findings and side-effects, were carried out before treatment and at the end of Weeks 1, 2 and 4. Psychometric tests, including the Taylor Manifest Anxiety Rating Scale, the von Zerssen Mood Self-Rating Scale, and the 11-item Freiburger Personality...

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