H‐2 Private Specificity of In VivoSensitized Lymphocytes Studied by Adsorption on Fibroblast Monolayers

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Abstract
Spleen cells or thymocytes immune to one H‐2 genotype are cytotoxic to allogeneic target cells of a third‐party genotype, provided the target shares private specificities determined by either the H‐2K or the H‐2D locus of the H‐2 complex with the H‐2 genotype used for sensitization in vivo. The present results on elimination of cytotoxicity to specificities determined by one of the H‐2 loci after adsorption of the immune lymphoid cells onto fibroblasts bearing this specificity suggest a state of diversity among effector lymphocytes reactive to the antigens determined by either the H‐2K or the H‐2D locus of the H‐2 complex. Thymus cells activated in vivo were less specifically adsorbable than spleen cells of tumor‐allografted mice.