Changes in lens during the formation of X-ray cataract in rabbits. 2

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Abstract
Glyceraldehyde phosphate dehydrogenase, glyoxalase, acetaldehyde oxidase, and aldolase, are present in the rabbit lens. The activities of glyceraldehyde phosphate dehydrogenase, glyoxalase, and acetaldehyde oxidase, fall during development of opacity in the lens after X-irradiation. The activity of aldolase is unchanged except in the opaque lens, when it is diminished. The content of coenzyme A and of nicotinic acid falls gradually during opacity development. The weight of the irradiated lens is less than that of the fellow-eye during the early stage of opacity formation. These results are discussed in relation to the known changes in glutathione and in protein sulfdryl groups in cataract.