Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus
- 12 July 1996
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 273 (5272) , 228-231
- https://doi.org/10.1126/science.273.5272.228
Abstract
The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.Keywords
This publication has 54 references indexed in Scilit:
- Measles virus receptor properties are shared by several CD46 isoforms differing in extracellular regions and cytoplasmic tailsJournal of General Virology, 1994
- Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cellsImmunology Today, 1994
- HIV and human complement: mechanisms of interaction and biological implicationImmunology Today, 1993
- Changes in Cytokine Production after Measles Virus Vaccination: Predominant Production of IL-4 Suggests Induction of a Th2 ResponseClinical Immunology and Immunopathology, 1993
- Complement Activation by gp160 Glycoprotein of HIV-1AIDS Research and Human Retroviruses, 1993
- Cellular immune responses during complicated and uncomplicated measles virus infections of manClinical Immunology and Immunopathology, 1984
- Measles: Summary of Worldwide ImpactClinical Infectious Diseases, 1983
- Measles virus vaccination of measles seropositive individuals suppresses lymphocyte proliferation and chemotactic factor productionClinical Immunology and Immunopathology, 1981
- Cell-Mediated Immunity during Natural Measles InfectionJournal of Clinical Investigation, 1978
- MEASLES VIRUS POLYPEPTIDES IN PURIFIED VIRIONS AND IN INFECTED CELLSActa Pathologica Microbiologica Scandinavica Section B Microbiology, 1978