A New Class of Highly Potent Farnesyl Diphosphate-Competitive Inhibitors of Farnesyltransferase
- 1 January 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 41 (2) , 143-147
- https://doi.org/10.1021/jm970540f
Abstract
No abstract availableThis publication has 14 references indexed in Scilit:
- Stereoselective synthesis of J-104,118 and J-104,123, novel, potent inhibitors of squalene synthaseTetrahedron, 1996
- J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogsBioorganic & Medicinal Chemistry Letters, 1996
- Efficient and stereoselective synthesis of J-104,118, a novel, potent inhibitor of squalene synthaseTetrahedron Letters, 1995
- Synthesis and biological activity of J-104,118, a novel, potent inhibitor of squalene synthaseBioorganic & Medicinal Chemistry Letters, 1995
- Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferaseDrug Development Research, 1995
- Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeuticCell, 1994
- Ras C-terminal processing enzymes—New drug targets?Cell, 1991
- Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptidesCell, 1990
- 2-Chloro-1,1,1-Triethoxyethane and its Use in a Versatile Synthesis of Substituted, 2-Chloromethyl Heterocycles Including Benzothiazole and BenzoxazoleSynthetic Communications, 1989
- Anti-Cram selective reduction of acyclic ketones via electron transfer initiated processesJournal of the American Chemical Society, 1988