No association of the ‐105 promoter polymorphism of the selenoprotein S encoding gene SEPS1 with cerebrovascular disease
- 26 July 2007
- journal article
- research article
- Published by Wiley in European Journal of Neurology
- Vol. 14 (10) , 1173-1175
- https://doi.org/10.1111/j.1468-1331.2007.01898.x
Abstract
A common pro-inflammatory promoter variant of the selenoprotein S encoding gene (SEPS1) was studied in young stroke patients from Italy and Germany and in healthy control subjects. The -105A-allele was found in 56 of 205 (27.3%) patients with ischemic stroke IS because of a spontaneous cervical artery dissection (CAD), and in 69 of 295 (23.4%) patients <50 years with IS of non-CAD origin. The SEPS -105A promoter variant was detected in 87 of 393 healthy control subjects (22.1%) and in 11 of 55 CAD patients without IS (20%). The non-significant differences of SEPS1 allele frequencies between disease groups and healthy controls suggest that the SEPS1 -105A allele is not a major-risk factor for stroke.Keywords
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