THE EFFECT OF CORTISONE, ADRENALECTOMY AND HYPOPHYSECTOMY ON THE TISSUE EOSINOPHIL COUNT IN THE GLANDULAR STOMACH OF THE RAT

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Abstract
The tissue eosinophil count of the lamina propria of the rat glandular stomach was quantitatively determined after cortisone administration, adrenalectomy and hypophysectomy. A single dose of cortisone increased the eosinophil count, the degree of tissue eosino-philia depending on the dose of cortisone used. Repeated administration of cortisone or adrenalectomy caused a decrease in the number of tissue eosinophils while hypophysectomy caused an increase. A large dose of atropine, 35 mg/100 body weight, increased the number of tissue eosinophils in intact animals within 1 hour of administration, but no increase occurred if the rat were pretreated with repeated doses of cortisone or was adrenalectomized. If, however, cortisone was given to adrenalectomized animals, the lamina propria eosinophils increased after atropine administration. These results support the concept that adrenal glucocorticoids are important in the production of tissue eosinophilia. It is suggested that when the number of circulating eosinophils decreases after cortisone treatment, these cells are directed to some tissues, including the lamina propria.

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