Intraneuronal effects of inhibitory amino acids
- 1 February 1980
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 58 (2) , 193-204
- https://doi.org/10.1139/y80-032
Abstract
Injections of γ-aminobutyric acid (GABA) into spinal motoneurons (in cats under Dial) induce a small but relatively prolonged hyperpolarization (mean −1.7 mV, SD 2. 1; n = 25), which is associated with a rise in input resistance (mean 44%, SD 122; n = 34), is not reversed by hyperpolarization, and is not potentiated by intracellular release of benzodiazepines. Muscimol sometimes has a comparable effect, but α-aminoisobutyric acid and glycine do not. These observations are consistent with the possibility that motoneurons have a Na+-coupled GABA transport mechanism that is electrogenic and can be reversed by an excess of intracellular GABA.This publication has 1 reference indexed in Scilit:
- MUSCIMOL UPTAKE, RELEASE AND BINDING IN RAT BRAIN SLICESJournal of Neurochemistry, 1978