The In vitro Effects of Penicillin on the Growth of Trichomonas foetus

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Abstract
Several manufacturer''s samples of penicillin, both amorphous and crystalline, were tested against T. foetus in vitro. On the basis of population counts, critical ranges of effectiveness were detd. The level of activity of amorphous penicillin, as measured by the inhibition of population growth, was appreciably higher than the level for the corresponding dose of crystalline penicillin. Evidence indicates that a factor is present in the non-penicillin residue of amorphous penicillin which greatly enhances the activity of the penicillin, although it has no activity by itself. When amorphous penicillin was inactivated by the addition of "Clarase," the resulting combination was more inhibitory for T. foetus than any of the other substances tested. In a test of 6 salts of penicillin, the ammonium salt had the greatest inhibitory effect on the population growth, although this culture lived 12/3 times as long as the control.
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