The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
Top Cited Papers
- 1 July 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 2 (7) , 489-501
- https://doi.org/10.1038/nrc839
Abstract
No abstract availableKeywords
This publication has 145 references indexed in Scilit:
- dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1Nature Cell Biology, 2002
- Drosophila PTEN Regulates Cell Growth and Proliferation through PI3K-Dependent and -Independent PathwaysDevelopmental Biology, 2000
- Induction of NF-κB by the Akt/PKB kinaseCurrent Biology, 1999
- Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systemsProceedings of the National Academy of Sciences, 1999
- High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceCurrent Biology, 1998
- Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTENCell, 1998
- Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersNature Genetics, 1997
- PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate CancerScience, 1997
- A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegansNature, 1996
- Phosphatidylinositol-3-OH kinase direct target of RasNature, 1994