Human T cell surface antigens bearing a structural relationship to HLA antigens.

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Abstract
Three cell surface antigens that are structurally related to the human major histocompatibility antigens (called HLA antigens) were characterized from the leukemic T cell line MOLT-4. One antigen is a glycoprotein of MW 49,000 recognized by 2 monoclonal antibodies, OKT6 and NA1/34, and is associated with a MW 12,000 subunit that crossreacts serologically with .beta.2-microglobulin but can be distinguished from it by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. A 2nd antigen, defined by the monoclonal antibody OKT10, is a MW 46,000 protein associated with a small subunit distinct from .beta.2-microglobulin. The OKT10 antigen is not restricted to T cells and is found on all T and B lymphoblastoid cell lines tested. The 3rd protein is a .beta.2-microglobulin-associated glycoprotein of MW 43,000 that is serologically distinct from the OKT6 (NA1/34), OKT10 and HLA antigens. It is found on some, but not all, T cell lines but is absent from any other hematopoeitic cell lines tested.