ESTRADIOL, ESTRONE, AND GONADOTROPIN-LEVELS AFTER USE OF VAGINAL ESTRADIOL

  • 1 January 1984
    • journal article
    • research article
    • Vol. 63  (4) , 441-444
Abstract
The vaginal absorption of 0.5 mg tablets of micronized estradiol was evaluated in postmenopausal women. In a single-dose study, 1 h after insertion, a 5.3-fold rise in mean serum estradiol levels and 1.5-fold rise in mean serum estrone levels were observed. Mean levels of luteinizing hormone and FSH were significantly depressed. In a 3 wk alternate-day regimen, mean serum levels of estradiol were consistently 2-3 times greater than those of estrone 12 h after insertion. Vaginal absorption of micronized estradiol tablets into the systemic circulation was rapid and efficient. The vaginal route was acceptable and well tolerated by patients. The major conversion of estradiol to estrone that follows oral or sublingual administration was reduced. The vagina may be a preferred alternate route for estrogen replacement therapy in selected patients.

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