Strontium-calcium interrelationships in the mature rat

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Abstract
The comparative metabolic behavior of strontium and calcium was studied in mature, female rats exposed both chronically and acutely to Sr90 and Ca45, while on diets of various total calcium contents. When orally administered, there is a discrimination against Sr90 relative to Ca45, apparent in the isotope levels in both blood and bone. This discrimination becomes smaller in magnitude as the level of calcium intake is increased. On all levels of calcium intake there is extensive exchange of calcium and strontium between bone and blood. On low-calcium diets the calcium moving from bone to blood is almost completely reutilized; as the level of dietary calcium is increased, this reutilization becomes less efficient and the rate of net removal of calcium from bone increases. In contrast, the rate of net removal of strontium from bone was relatively insensitive to changes in dietary calcium level, and on all diets was similar to the rate of net removal of calcium on the highest calcium diet.

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