Influence of Phosphorylated Hesperidin on Fat Tolerance Curves in Vivo and in Vitro

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Abstract
By means of a standard fat tolerance test the anti-lipemic effect following intraven. admn. of phosphorylated hesperidin was noted in 12 humans, in in vivo and in vitro studies. Since the same subjects were studied by the same technique in previous expts., using heparin as the anti-lipemic agent instead of hesperidin, it was possible to compare the results. Phosphorylated hesperidin had anti-lipemic properties similar to heparin, but not as marked. After hesperidin admn., the anti-lipemic effect lasted longer with less rebound of the lipemic curve when the anti-lipemic effect was dissipated. When a subject''s turbid serum was mixed with his post-hesperidin serum and incubated at 37[degree]C clearing occurred as in the heparin expts. Marked individual variation was noted in the formation of clearing factor. The possible mechanisms whereby 2 dissimilar substances such as heparin and hesperidin exert their anti-lipemic effect is discussed.