Recurrence risks for down syndrome
- 1 August 1980
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 55 (2) , 203-208
- https://doi.org/10.1007/bf00291768
Abstract
The recurrence risks for Down syndrome due to an inherited translocation are estimated from empirical data in the literature for two maternal age groups: mothers under 30 and mothers 30 and over. These risks were found to be approximately 0.3% and 0.05%, respectively. The probability for two Down syndrome sibs both having an inherited translocation was estimated as about 18.2% for the former age group and 2.7% for the latter. The relative effectiveness in preventing Down syndrome births by karyotyping affected children is discussed.This publication has 12 references indexed in Scilit:
- La trisomie 4pHuman Genetics, 1975
- Down's syndromeHuman Genetics, 1971
- Statistical inference on segregation ratios for D/G-translocations, when the families are ascertained in different waysAnnals of Human Genetics, 1970
- A Statistical Segregation Analysis of (21q22q)-translocationsHuman Heredity, 1970
- Genetic Counselling in Down’s SyndromeHuman Heredity, 1970
- Detection of Higher Recurrence Risk for Age-Dependent Chromosome Abnormalities with an Application to Trisomy G1 (Down’s Syndrome)Human Heredity, 1970
- Consistent and variable chromosome anomalies in parents of children with Down's syndrome.Journal of Medical Genetics, 1969
- [A study of the offspring of t(21q Dq) translocation carriers].1969
- A Survey of Mongoloid Births in Victoria, Australia, 1942-1957American Journal of Public Health and the Nations Health, 1962
- RISK OF PARENTS WHO HAVE HAD ONE CHILD WITH DOWN'S SYNDROME (MONGOLISM) HAVING ANOTHER CHILD SIMILARLY AFFECTEDThe Lancet, 1961