Effect of growth hormone on carbohydrate metabolism in normal and hypophysectomized dogs; studies with C14 glucose

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Abstract
Using trace amounts of C14 glucose, introduced intravenously by a priming injection along with a continuous constant infusion, the effect of a growth hormone regimen on the size of body glucose pool and on the rate of glucose utilization as well as production was studied in unanesthetized normal and hypophysectomized dogs. In both types of animals the growth hormone regimen increased the size of the body glucose pool. More significantly the growth hormone regimen increased the rate of glucose utilization as well as the rate of glucose production. It is proposed that the inhibitory effect of injected growth hormone on glucose uptake observed in isolated diaphragm is overcome in vivo by an increased endogenous insulin secretion evoked by the extra glucose produced as a result of the growth hormone treatment.