Autonomic disturbances in spinal cord lesions

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Abstract
Key points Migraine is considered a neurovascular disorder. - Cerebrovascular regulatory dysfunction may be implicated in migraine pathophysiology. - Cerebrovascular regulation is complex and involves autonomic, trigeminovascular, endothelial, and humoral factors. - Some studies of autonomic regulation in migraine suggest parasympathetic hypofunction. - NO and calcitonin-gene-related peptide may be important transmitters in migraine. - A further understanding of autonomic involvement and the molecular mechanisms of migraine seems near and new therapies are likely to evolve.

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