Incidence of Liver Tumors in Male and Female Rats Fed Carcinogenic Azo Dyes
- 1 February 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 100 (2) , 320-322
- https://doi.org/10.3181/00379727-100-24613
Abstract
Osborne-Mendel rats fed p-dimethylaminobenzene − 1-azo − 1-naphthalene (DAN) and p-dimethylaminoazobenzene (DAB) showed a higher incidence of liver tumors in males than in females. In DAN fed rats the respective incidence was 75 and 17% and in DAB fed rats 85 and 19%. Feeding higher doses of DAN (0.3%) to rats, failed to shorten the induction period for this compound. Rats fed p-dimethylaminobenzene-1-azo-2-naphthalene (DA-2-N) showed no significant difference in incidence of liver tumors between males (98%) and females (100%). However, tumors were much slower in appearing in females than in males, indicating relative resistance of the female liver to carcinogenesis induced by DA-2-N.Keywords
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