Substance P Immunoreactivity in Alzheimer Disease
- 1 January 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Alzheimer Disease & Associated Disorders
- Vol. 4 (1) , 24-34
- https://doi.org/10.1097/00002093-199040100-00003
Abstract
Substance P-like immunoreactivity was visualized by immunohistochemical methods in 20 postmortem brains: 6 senile, 4 presenile Alzheimer dementia (AD), 3 AD with interhemispheric asymmetric cortical atrophy, and 7 control cases. For all pathological cases, the SP-like immunoreactivity was significantly reduced in the neocortical areas and in the hippocampus. This contrasted with an enhanced SP-like immunoreactivity in the pallidum and the substantia nigra in AD brains and a more pronounced SP-like immunoreactivity in the more atrophic side in the asymmetrically atrophied brains.Keywords
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