Prognosis in Hyaline-Membrane Disease

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Abstract
THE pathological diagnosis of hyaline-membrane disease is made at autopsy in approximately 30 per cent1 of infants who die in the neonatal period. The characteristic pathological changes are found in 40 to 60 per cent of infants whose birth weight is less than 2500 gm. Although the diagnosis in surviving infants cannot be established by any pathognomonic clinical or laboratory feature, or any combination of features, a clinical, biochemical and radiological pattern is usually characteristic enough to be separable from other causes of respiratory distress in newborn infants. A wide range of severity occurs among infants with this clinical syndrome. . . .