Inositol hexaphosphate inhibits large intestinal cancer in F344 rats 5 months after induction by azoxymethane
- 1 March 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 10 (3) , 625-626
- https://doi.org/10.1093/carcin/10.3.625
Abstract
A treatment regimen of 2% Na-InsP6 fin drinking water was effective in significantly reducing large intestinal cancer in F344 rats even when the treatment was begun 5 months after carcinogenic induction with azoxymethane (AOM 8 mg/kg/wk × 6). Compared to untreated (AOM-only) rats, animals on InsP6 had 27% fewer tumors (P < 0.02). The tumors were approximately two-thirds smaller in size (P < 0.01) and percentage mitotic rate in the non-neoplastic epithelium was less than half (1.0 ± 0.1, compared to 2.3 ± 0.2 of AOM-only animals, significant at P < 0.001). We postulate that InsP6 may exert its antineoplastic effect by way of regulating cellular proliferation even after effective carcinogenic stimuli and thus may be an important candidate for chemointervention.This publication has 0 references indexed in Scilit: