Continuous Secretin Infusion with Pancreozymin Pretreatment as a Pancreatic Function Test

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Abstract
A pancreatic function test is examined with the submaximal dose of secretin given by continuous infusion after injection of cholecystokinin-pancreozymin (CCK-PZ) in the submaximal dose. The active elimination of bladder bile by CCK-PZ pretreatment decreased the influence of biliary contamination, and the volume output and the bicarbonate concentration were stabilized by the continuous infusion of secretion. The coefficients of variation in the volume output and the bicarbonate concentration were calculated to be about 15 and 5%, respectively. These variations were considerably smaller than those obtained in the standard secretin test. The present study is expected to improve the diagnostic means for human pancreatic excretory dysfunction.