MECHANISMS OF DESOXYCORTICOSTERONE ACTION: IV. RELATIONSHIP OF FLUID INTAKE AND PRESSOR RESPONSES TO OUTPUT OF ANTIDIURETIC FACTOR

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Abstract
Subcut. implantation of desoxy-corticosterone in rats was followed by increases in fluid intake, blood pressure and urinary output of antidiuretic factor. Substitution of isotonic salt soln. for drinking water in animals not treated with desoxycorticosterone produced an increased output of antidiuretic factor unaccompanied by significant blood pressure elevation. The urinary output of antidiuretic factor was proportional to the degree of elevation of fluid intake, whether increased intake was produced by salt admn. alone, desoxycorticosterone alone, or a combination of both. The evocation of antidiuretic factor excretion by desoxycorticosterone would appear to be a consequence of the disturbance in fluid exchange. A direct relationship of this factor to the development of hypertension was not established.