Persistent Infection of Continuous Line of Pig Kidney Cells with a Variant of the WSN Strain of Influenza A0 Virus

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Abstract
RES cells were infected with the RES16 variant of the WSN strain of influenza A0 virus and the culture medium changed at frequent intervals; five lines of cells were established in which infection was sustained for periods of 126 to 146 days. Each line of persistently-infected cells showed recurring cycles of cell degeneration and repopulation; these cultures did not remain in equilibrium with the virus indefinitely, however, and ultimately degenerated.