Abstract
The obvious approach to the study of personality seems to be psychologic, since most of the attributes of personality appear to be in this field and in the field of the emotions. This statement does not mean, however, that there may not be also a physical basis of the personality and emotions. Attempts to determine what this physical factor consists of have been made in the past with relatively scant success. More recently attention has been directed to changes in personality and mood associated with disease of the hypothalamus. There appears to be both clinical and experimental proof that this region is in some way associated with the regulation of personality and mood and that lesions in this region may cause changes in personality and mood. The case which is reported in this paper appears to throw further light on this problem. REPORT OF CASE Diabetes insipidus; marked personality changes;

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